Adriamycin and daunomycin produced significant cardiovascular effects including bradycardia, hypotension, and ventricular arrhythmias in hamsters and monkeys, whereas N-acetyldaunomycin caused minimal changes.
The most consistent initial effects of adriamycin (12.5–50.0 mg/kg) in hamsters and rhesus monkeys were bradycardia, hypotension, ventricular arrhythmias and respiratory depression. Daunomycin (50 mg/kg) produced ventricular arrhythmias at twice the dose of adriamycin. In both species large doses of N-acetyldaunomycin (200 mg/kg) caused only minimal changes in all parameters. Significant amounts of all 3 parent compounds were detected in hamster heart and lung tissues soon after injection. A relatively rapid conversion of both daunomycin and adriamycin to the aglycone was found, but a significantly higher percentage of the adriamycin aglycone was concentrated in these 2 tissues. In contrast, relatively little conversion of N-acetyldaunomycin was detected. Thus, the observed pharmacological actions may be related to differences in metabolism of the 3 compounds.
Herman et al. (Wed,) reported a other. Adriamycin, daunomycin, and N-acetyldaunomycin was evaluated on Cardiovascular effects (bradycardia, hypotension, ventricular arrhythmias) and respiratory depression. Adriamycin and daunomycin produced significant cardiovascular effects including bradycardia, hypotension, and ventricular arrhythmias in hamsters and monkeys, whereas N-acetyldaunomycin caused minimal changes.
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