Spontaneous and ADP-induced platelet aggregation inversely correlated with pre-exercise (r=-0.32, P<0.05) and post-exercise ABPI (r=-0.34, P<0.05), indicating an association with PAD severity.
Cross-Sectional (n=31)
Is platelet hyperactivity associated with the severity of peripheral arterial disease?
Platelet hyperactivity is associated with increasing severity of peripheral arterial disease, suggesting a potential mechanism for thromboembolic events in affected limbs.
Effect estimate: r = -0.32
p-value: p=<0.05
Peripheral arterial disease (PAD) is a chronic fibroproliferative inflammatory condition associated with progressive vascular stenosis. We set out to determine the relationship between spontaneous stirring-induced platelet aggregation in whole blood and the severity of lower-limb PAD, represented by the ankle-brachial pressure index (ABPI). ABPI was determined pre- and post-exercise in 31 subjects (20 men and 11 women) with established PAD. Platelets counts were determined in EDTA blood (total count) and in citrated whole blood after stirring in the absence of added ADP (spontaneous aggregation) and in the presence of added ADP (ADP-induced) for 3 min at 37 degrees C. Aggregation was calculated as a percentage of the total platelet count. Spontaneous platelet aggregation showed an inverse correlation with pre-exercise ABPI (r = -0.32; P < 0.05) and ADP-induced aggregation correlated inversely with post-exercise ABPI (r = -0.34; P < 0.05). These results indicate that platelet hyperactivity is associated with increasing severity of PAD. Increased platelet aggregation may result in thromboembolic events in the affected limb.
Smith et al. (Mon,) conducted a cross-sectional in Peripheral arterial disease (n=31). Platelet aggregation assessment was evaluated on Correlation between spontaneous/ADP-induced platelet aggregation and ankle-brachial pressure index (ABPI) (r = -0.32, p=<0.05). Spontaneous and ADP-induced platelet aggregation inversely correlated with pre-exercise (r=-0.32, P<0.05) and post-exercise ABPI (r=-0.34, P<0.05), indicating an association with PAD severity.