3-dimensional echocardiography-derived diastolic and systolic remodeling indices significantly correlated with pulmonary vascular resistance (R=0.67, P=0.0005 and R=0.55, P=0.006, respectively).
Observational (n=23)
Does 3-dimensional echocardiography accurately reflect invasive hemodynamic changes in patients with pulmonary hypertension?
Novel 3D echocardiography indices, particularly the diastolic remodeling index (RVEDVI/LVEDVI), strongly correlate with invasive pulmonary vascular resistance and may serve as non-invasive indicators of hemodynamic severity in pulmonary hypertension.
Effect estimate: R=0.67
p-value: p=0.0005
BACKGROUND: Non-invasive assessment of volume and function on the right ventricle (RV) for pulmonary hypertension (PH) is limited. METHODS AND RESULTS: Patients with PH (n=23) underwent 3-dimensional (D) echocardiography (3DECHO), with cardiac magnetic resonance imaging to confirm its precision, and right heart catheterization. On linear regression analysis the RV end-systolic volume index (ESVI) was positively correlated with pulmonary vascular resistance (PVR) and mean pulmonary arterial pressure (mPAP; R=0.42 and 0.46, P=0.03 and 0.03, respectively). The RV end-diastolic volume index (EDVI) was positively correlated with mPAP (R=0.41, P<0.05). The left ventricular (LV) EDVI was inversely correlated with PVR (R=-0.48, P=0.02). The RV ejection fraction was inversely correlated with PVR and mean right atrial pressure (mRAP; R=-0.57, and -0.45, P=0.004, and 0.03, respectively). RVEDVI/LVEDVI and RVESVI/LVESVI (the diastolic and systolic remodeling indices, respectively) had a significantly positive linear relationship with PVR (R=0.67 and 0.55, P=0.0005 and 0.006, respectively), and the former had a significantly positive linear relationship with mRAP (R=0.42, P<0.05). During the recovery process in 1 specific case, the remodeling indices maintained a significant linear relationship with the hemodynamic parameters. CONCLUSIONS: Novel indices provided by 3DECHO may be utilized as alternative indicators of hemodynamic changes in PH patients.
Inaba et al. (Fri,) conducted a observational in Pulmonary hypertension (n=23). 3-dimensional echocardiography vs. Cardiac magnetic resonance imaging and right heart catheterization was evaluated on Correlation of diastolic remodeling index (RVEDVI/LVEDVI) with pulmonary vascular resistance (R=0.67, p=0.0005). 3-dimensional echocardiography-derived diastolic and systolic remodeling indices significantly correlated with pulmonary vascular resistance (R=0.67, P=0.0005 and R=0.55, P=0.006, respectively).