Pericardial fluid adenosine deaminase (cutoff 72 U/l) and lysozyme (cutoff 6.5 microg/dl) demonstrated 100% sensitivity and >91% specificity for diagnosing tuberculous pericarditis.
Observational (n=41)
Does the measurement of pericardial fluid adenosine deaminase (ADA) and lysozyme (Lys) accurately diagnose tuberculous pericarditis in patients with significant pericardial effusion?
Pericardial fluid ADA and lysozyme measurements are highly sensitive and specific biomarkers for the diagnosis of tuberculous pericarditis in patients with significant pericardial effusion.
OBJECTIVE: To assess the value of pericardial fluid adenosine deaminase (ADA) and pericardial lysozyme (Lys) as tools in diagnosing tuberculous pericarditis. METHODS: Forty-one patients (age range 17--77 years) with significant pericardial effusion were included in the study. Diagnostic pericardiocentesis and pericardial biopsy were performed while serum and pericardial fluid ADA and Lys were measured in all patients. Grouping of patients resulted as follows: group I = 7 patients with tuberculous pericarditis; group II = patients with neoplastic pericarditis; group III = 30 patients with idiopathic pericarditis. RESULTS: Pairwise multiple comparison procedures revealed a significant difference of ADA in group I versus group III (p < 0.05) but not versus group II. Furthermore, pericardial Lys in group I was higher than in groups II and III (p < 0.05). A strong correlation between pericardial ADA and Lys was found (r = 0.733, p = 0.01) for all the patients. Receiver operating curves showed a value of 72 U/l as cutoff point of pericardium ADA, with a sensitivity of 100% and a specificity of 94% in the diagnosis of tuberculous pericarditis. Similarly for pericardial Lys, a value of 6.5 microg/dl had a sensitivity and specificity of 100 and 91.17%, respectively. CONCLUSIONS: Both measurements of pericardial ADA and Lys need to be taken into account when attempting the early diagnosis of tuberculous pericarditis.
Aggeli et al. (Sat,) conducted a observational in Tuberculous pericarditis (n=41). Pericardial fluid adenosine deaminase (ADA) and lysozyme (Lys) measurements vs. Neoplastic and idiopathic pericarditis was evaluated on Diagnostic sensitivity and specificity for tuberculous pericarditis. Pericardial fluid adenosine deaminase (cutoff 72 U/l) and lysozyme (cutoff 6.5 microg/dl) demonstrated 100% sensitivity and >91% specificity for diagnosing tuberculous pericarditis.
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