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Given a finite tree, some of whose vertices are identified with given finite sequences, we show how to construct sequences for all the remaining vertices simultaneously, so as to minimize the total edge-length of the tree. Edge-length is calculated by a metric whose biological significance is the mutational distance between two sequences.
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David Sankoff (Wed,) studied this question.
www.synapsesocial.com/papers/69d776df9c65a8c80448f7e6 — DOI: https://doi.org/10.1137/0128004
David Sankoff
SIAM Journal on Applied Mathematics
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