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A Simple Method for the Determination of Glomerular Filtration Rate | Synapse

January 1, 1972

A Simple Method for the Determination of Glomerular Filtration Rate

Key Points

This research aims to develop a straightforward method for determining glomerular filtration rate in patients with renal diseases.
Compared total [51Cr]EDTA plasma clearance to [51Cr]EDTA clearance using a one-pool system in 74 adult patients with renal diseases.
Calibrated the clearance values and provided an equation for correction.
Cl1 (clearance assuming the one-pool system) always exceeded Cl (total plasma clearance).
The relative difference between Cl1 and Cl increased as the clearance values rose.

Abstract

In 74 adult patients suffering from various renal diseases, the total 51CrEDTA plasma clearance (Cl) was compared to the 51CrEDTA clearance obtained on assuming a one-pool system (Cl1). Cl1 always exceeded Cl, and the relative difference increased with increasing clearance values. An equation for correction is given. The method for determining Cl1 is very simple and suitable for clinical routine examinations.

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Cite This Study

Jens Brøchner‐Mortensen (Sat,) studied this question.

synapsesocial.com/papers/6a00220a2ff633f36577d2b6 https://doi.org/https://doi.org/10.3109/00365517209084290