September 8, 2014
View Full PaperPharmacology and mechanisms of action of new oral anticoagulants
Key Result
New oral anticoagulants, including direct anti-Xa and anti-IIa agents, exhibit heterogeneous pharmacological profiles despite their shared indication for stroke prevention in atrial fibrillation.
Structured PICO
I
Intervention
New direct anti-Xa and anti-IIa agents (new oral anticoagulants)
This review provides a summary of the pharmacological characteristics and mechanisms of action of new direct anti-Xa and anti-IIa oral anticoagulants.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
The new oral anticoagulants are announced as an important therapeutic revolution, particularly after their approval by authorities for stroke prevention in atrial fibrillation. However, the pharmacology of these new drugs is not homogeneous. In this review, we summarize the main pharmacological characteristics of the new direct anti-Xa and anti-IIa agents.