Newer generation ICU scoring systems accurately predicted ICU mortality in patients with sepsis, with SOFA achieving the highest AUROC of 0.889, though differences among scores were not statistically significant.
Observational (n=438)
No
Low TAFI activity predicts mortality and multiple organ dysfunction syndrome in patients with sepsis-induced disseminated intravascular coagulation.
Effect estimate: AUROC 0.889 (95% CI 0.857-0.922)
Introduction Fibrinolytic shutdown plays a pivotalrole in the pathogenesis of multiple organ dysfunction syndrome (MODS) in disseminated intravascular coagulation (DIC). We tested the hypothesis that the levels of thrombin activatable fi brinolysis inhibitor (TAFI) are not suffi cient to overcome fi brinolytic shutdown, thus contributing to MODS and the poor prognosis in sepsis-induced DIC. Methods Fifty patients with sepsis, severe sepsis, or septic shock were enrolled in the study. The DIC was diagnosed based on the Japanese Association for Acute Medicine (JAAM) DIC criteria. The overt DIC scores based on the International Society on Thrombosis and Haemostasis (ISTH) were also calculated. On the day of sepsis diagnosis (day 1), and days 3 and 5, we measured TAFI, soluble fi brin, and global coagulation and fi brinolysis markers.
Juneja et al. (2011) conducted an observational in Sepsis (n=438). ICU scoring systems (SOFA, APACHE, SAPS, MPM) was evaluated on ICU mortality prediction (AUROC for SOFA) (AUROC 0.889, 95% CI 0.857-0.922). Newer generation ICU scoring systems accurately predicted ICU mortality in patients with sepsis, with SOFA achieving the highest AUROC of 0.889, though differences among scores were not statistically significant.