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In his book Analysis of Human Genetic Linkage Jurg Ott laid out the principles by which geneticists perform studies of genetic linkage in humans. Here, in the Handbook of Human Genetic Linkage, Joseph Terwilliger and Jurg Ott provide a companion piece to the previous work, showing how its principles may be applied in practice. Handbook of Human Genetic Linkage contains detailed instructions on how to carry out linkage analysis, guiding the reader through each process on a step-by-step basis. The chapters are grouped into three main sections: two-point linkage analysis, multi-point linkage analysis, and such advanced topics as mutation rates, gene frequencies, linkage disequilibrium, complex diseases and computer simulation. Each chapter ends with exercises that can be performed on an IBM PC-compatible computer. The solutions are supplied at the end of each section.
Edwards et al. (Sun,) studied this question.