Abnormal Leukocyte Response in Alcoholism

Article1 December 1963Abnormal Leukocyte Response in AlcoholismWILLIAM MCFARLAND, M.D., F.A.C.P., EUGENE P. LIBRE, M.D.WILLIAM MCFARLAND, M.D., F.A.C.P.Search for more papers by this author, EUGENE P. LIBRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-865 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHematologic abnormalities are well-recognized in cirrhosis of the liver and studies to elucidate the cause usually incriminate the advanced liver disease and secondary splenomegaly with resultant hypersplenism. Recently, however, studies have suggested that liver disease and hypersplenism may not be essential etiologic factors. In a group of alcoholic patients studied by Jandl (1), the hematologic findings in two patients led him to suspect a direct suppression of the bone marrow by alcohol. In a later report, McCurdy, Pierce, and Rath (2) have demonstrated vacuolization of erythrocyte precursors in the marrows of acute alcoholics similar to the changes observed in the...References1. JANDL JH: The anemia of liver disease: observations on its mechanism. J. Clin. Invest. 34: 390, 1955. CrossrefMedlineGoogle Scholar2. MCCURDYPIERCERATH PRLECE: Abnormal bone marrow morphology in acute alcoholism. New Eng. J. Med. 266: 505, 1962. CrossrefGoogle Scholar3. BRECHERCRONKITE GEP: Morphology and enumeration of blood platelets. J. Appl. Physiol. 3: 365, 1950. CrossrefMedlineGoogle Scholar4. MCFARLANDDAMESHEK WW: Biopsy of bone marrow with the Vim-Silverman needle. JAMA 166: 1464, 1958. CrossrefMedlineGoogle Scholar5. BREWERTARLOVALVING GJARAS: Methemoglobin reduction test: a new, simple in vitro test for identifying primaquine sensitivity. Bull. WHO 22: 633, 1960. MedlineGoogle Scholar6. MECHANICFREILANDYSMITH RCEMWW: Quantitative studies of human leukocyte and febrile response to single and repeated doses of purified bacterial endotoxin. J. Clin. Invest. 41: 162, 1962. CrossrefMedlineGoogle Scholar7. CRADDOCKPERRYVENTZKELAWRENCE CGSLEJS: Evaluation of marrow granulocytic reserves in normal and disease states. Blood 15: 840, 1960. CrossrefMedlineGoogle Scholar8. HEILMEYER I: Funktionsprufung der Leukopoese des Knochenmarks. Deutsch. Med. Wschr. 82: 644, 1957. CrossrefMedlineGoogle Scholar9. KELLER HM: Knochenmarksfunktion bei Lebererkronkungen und Splenomegalien, untersucht mit unspezifischen Reizstoff. European Society Hematology, Proceedings, 5th meeting. (Freiburg) Germany, 1955. Google Scholar10. LEEVY CM: A study of 270 patients with biopsy proven fatty liver and a review of the literature. Medicine (Balt.) 41: 249, 1962. CrossrefMedlineGoogle Scholar11. ZIEVE L: Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann. Intern. Med. 48: 471, 1958. LinkGoogle Scholar12. WHIPPLEHARRIS RLJF: B. coli septicemia in Laennec's cirrhosis of the liver. Ann. Intern. Med. 33: 462, 1950. LinkGoogle Scholar13. MARTINMCHENRYWELLMANBAGGENSTROSS WJMCWEAH: Severe liver disease complicated by bacteremia. Arch. Intern. Med. (Chicago) 109: 101, 1962. CrossrefGoogle Scholar14. KORNBERGDAFTSEBRELL AFSWH: Dietary granulocytopenia in rats corrected by crystalline L. Casei factor ("folic acid"). Proc. Soc. Exp. Biol. Med. 58: 46, 1945. CrossrefGoogle Scholar15. JANDLLEAR JHAA: The metabolism of folic acid in cirrhosis. Ann. Intern. Med. 45: 1027, 1956. LinkGoogle Scholar16. CARTERHELLERSCHAFFNERKORN FCPGRJ: Formiminoglutamic acid (FIGLU) excretion in hepatic cirrhosis. Arch. Intern. Med. (Chicago) 108: 41, 1961. CrossrefMedlineGoogle Scholar17. GUSSOFFLEELICHTMAN BDSLHC: Erythropoietic changes during therapy with chloramphenicol. Arch. Intern. Med. (Chicago) 109: 176, 1962. CrossrefMedlineGoogle Scholar18. WAISBRENSIMSKICHANG BACPL: Administration of maximum doses of chloramphenicol. Amer. J. Med. Sci. 245: 1, 1963. CrossrefMedlineGoogle Scholar19. LIEBERDAVIDSON CSCS: Some metabolic effects of ethyl alcohol. Editorial. Amer. J. Med. 33: 319, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.From the Departments of Medicine, Veterans Administration Hospital and Georgetown University, Washington, D. C.Supported by grant AM-07907 from the United States Public Health Service, Bethesda, Maryland.Dr. Libre is a postdoctoral Fellow in Hematology, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to William McFarland, M.D., Hematology Section, Veterans Administration Hospital, 2650 Wisconsin Avenue Northwest, Washington 7, D. C. 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COWAN, M.D., JOHN D. HINES, M.D.Acute and Chronic Toxicity of AlcoholTransient Stomatocytosis with Hemolysis: A Previously Unrecognized Complication of AlcoholismCHARLES C. DOUGLASS, M.D., JEREMIAH J. TWOMEY, M.B., F.A.C.P.Effect of Alcohol and Various Diseases on Leukocyte Mobilization, Phagocytosis and Intracellular Bacterial KillingAlcohol, Infection, and the LungAlkohol und BlutThe effect of chronic alcohol administration on the immune responsiveness of ratsOCCULT BLOOD IN FÆCESALCOHOL AND THE BLOODHematologic Effects of Alcohol in Man in the Absence of Nutritional DeficiencyPolymorphonuclear leukocyte motility in vitro. I. Effect of pH, temperature, ethyl alcohol, and caffeine, using a modified boyden chamber technicBIBLIOGRAPHYThrombocytopenia and AlcoholismROBERT M. POST, M.D., JANE F. DESFORGES, M.D.Thrombocytopenia in AlcoholicsJOHN LINDENBAUM, M.D., R. LESLIE HARGROVE, M.D.Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute LeukemiaGERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.LeukopeniaErrors and Hazards in the Diagnosis and Treatment of Bacterial PneumoniasJONAS A. SHULMAN, M.D., LEON A. PHILLIPS, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P. 1 December 1963Volume 59, Issue 6Page: 865-877KeywordsAlcoholicsBloodBone marrowCellsHematocritLymphocytesMonocytesNeutrophilsPneumoniaWhite blood cells Issue Published: 1 December 1963 PDF downloadLoading ...