Patterns of Immunological Deficiency in Lymphomas and Leukemias

Article1 November 1962Patterns of Immunological Deficiency in Lymphomas and LeukemiasDANIEL G. MILLER, M.D.DANIEL G. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-703 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally appreciated that immunological abnormalities are associated with lymphomas and leukemias. In the last decade, there has been a growing interest in the immunological aspect of these diseases, which stems from the widespread use of electrophoretic techniques and increasing emphasis on the natural history and complications of these diseases. Such studies have prompted speculation that there may be significant differences in the way the immune system is affected by the diseases included in the categories of lymphoma and leukemia. The purpose of this paper is to examine laboratory and clinical studies of immunological functions and to determine if...References1. BROWNREADWISEMANFRANCE RKJTBKWG: The electrophoretic analysis of serum proteins of the blood dyscrasias. J. Lab. Clin. Med. 33: 1523, 1948. MedlineGoogle Scholar2. CREYSSELMORELPELLETMEDARDREVOLCROIZAT RPMJLP: Deficit en gammaglobulines et complications infectieuses des leucemies lymphoides chroniques. Sang 29: 383, 1958. MedlineGoogle Scholar3. GROSSGITLINJANEWAY PADCA: The gamma globulins and their clinical significance. III. Hypergammaglobulinemia. New Engl. J. Med. 260: 121, 1959. CrossrefMedlineGoogle Scholar4. HUDSONWILSON RSJ: Hypogammaglobulinemia and chronic lymphatic leukemia. J. Lab. Clin. Med. 50: 829, 1957. Google Scholar5. JIMREINHARD RTEH: Agammaglobulinemia and chronic lymphocytic leukemia. Ann. Intern. Med. 44: 790, 1956. LinkGoogle Scholar6. MILLERKARNOFSKY DGDA: Immunologic factors and resistance to infection in chronic lymphatic leukemia. Amer. J. Med. 31: 748, 1961. CrossrefMedlineGoogle Scholar7. OSSERMAN EF: Plasma-cell myeloma. II. Clinical aspects. New Engl. J. Med. 261: 1006, 1959. CrossrefMedlineGoogle Scholar8. PRASAD A: The association of hypogammaglobulinemia and chronic lymphatic leukemia. Amer. J. Med. Sci. 236: 610, 1958. MedlineGoogle Scholar9. SELIGMANNALAISBERNARD MLJ: Analyse immunoelectrophoretique du serum de cent malades atteints de leucoses. Rev. Franc. Etudes Clin. Biol. 4: 901, 1959. MedlineGoogle Scholar10. SHAWSZWEDBOGGSFAHEYFREIMORRISONUTZ RKCDRJLEEJP: Infection and immunity in chronic lymphocytic leukemia. Arch. Intern. Med. 106: 467, 1960. CrossrefGoogle Scholar11. SUNDERMANSUNDERMAN FWFW: Clinical applications of the fractionation of serum proteins by paper electrophoresis. Amer. J. Clin. Path. 27: 125, 1957. CrossrefMedlineGoogle Scholar12. ULTMANNFISHOSSERMANGELLHORN JEWEA: The clinical implications of hypogammaglobulinemia in patients with chronic lymphocytic leukemia and lymphocytic lymphosarcoma. Ann. Intern. Med. 51: 501, 1959. LinkGoogle Scholar13. SILVERUTZFREIMCCULLOUGH RTJPENB: Fever, infection and host resistance in acute leukemia. Amer. J. Med. 24: 25, 1958. CrossrefMedlineGoogle Scholar14. CAPONEROSSI-ESPAGNETRUGGERI MAP: Agammaglobulinemia in paziente con mielosi leucemica cronica: studio clinico, elettroforetico ed immunologico. Policlinico 62: 1125, 1955. MedlineGoogle Scholar15. HEREMANS JF: Immunochemical studies on protein pathology. The immunoglobulin concept. Clin. Chim. Acta 4: 639, 1959. CrossrefMedlineGoogle Scholar16. MORESCHI C: Ueber antigene und pyrogene Wirkung des Typhus Bacillus bei leukämischen Kranken. Z. Immunitaetsforsch. 21: 410, 1914. Google Scholar17. ROTKY H: Ueber die Fähigkeit von Leukämikern, Antikörper zu erzeugen. Zbl. Inn. Med. 35: 953, 1914. Google Scholar18. HOWELL KM: The failure of antibody formation in leukemia. Arch. Intern. Med. 26: 706, 1920. CrossrefGoogle Scholar19. LARSONTOMLINSON DLLJ: Quantitative antibody studies in man. III. Antibody response in leukemia and other malignant lymphomata. J. Clin. Invest. 32: 317, 1953. CrossrefMedlineGoogle Scholar20. GELLER W: A study of antibody formation in patients with malignant lymphomas. J. Lab. Clin. Med. 42: 232, 1953. MedlineGoogle Scholar21. ZINNEMANHALL HHWH: Recurrent pneumonia in multiple myeloma and some observations on immunologic response. Ann. Intern. Med. 41: 1152, 1954. LinkGoogle Scholar22. SILVERUTZFAHEYFREI RTJPJLE: Antibody response in patients with acute leukemia. J. Lab. Clin. Med. 56: 634, 1960. Google Scholar23. EVANS RW: The antibody response in cases of radiation lymphopenia, and in the reticuloses. J. Path. Bact. 60: 123, 1948. CrossrefMedlineGoogle Scholar24. MILLERLIZARDOSNYDERMAN DGJGRA: Homologous and heterologous skin transplantation in patients with lymphomatous disease. J. Nat. Cancer Inst. 26: 569, 1961. MedlineGoogle Scholar25. HOFFMANROTTINO GTA: Studies of immunologic reactions of patients with Hodgkin's disease. Antibody reaction to typhoid immunization. Arch. Intern. Med. 86: 872, 1950. CrossrefGoogle Scholar26. SASLAWCARLISLEBOURONCLE SHNB: Antibody response in hematologic patients. Proc. Soc. Exp. Biol. Med. 106: 654, 1961. CrossrefMedlineGoogle Scholar27. SCHIERROTHOSTROFFSCHRIFT WWAGMH: Hodgkin's disease and immunity. Amer. J. Med. 20: 94, 1956. CrossrefMedlineGoogle Scholar28. FORBUSGODDARDMARGOLISBROWNKERBY WDDWGIWGP: Studies on Hodgkin's disease and its relation to infection by brucella. Amer. J. Path. 18: 745, 1942. Google Scholar29. WISEPOSTON NBMA: The coexistence of brucella infection and Hodgkin's disease. A clinical, bacteriologic and immunologic study. JAMA 115: 1976, 1940. CrossrefGoogle Scholar30. BARRFAIRLEY MGH: Circulating antibodies in the reticuloses. Lancet 1: 1305, 1961. CrossrefMedlineGoogle Scholar31. BERNSTEIN A: The diagnostic importance of the heterophile antibody test in leukemia. J. Clin. Invest. 13: 677, 1934. CrossrefMedlineGoogle Scholar32. WEINSTEINFITZ-HUGH GLT: The heterophil antibody test in leukemia and leukemoid conditions. Amer. J. Med. Sci. 190: 106, 1935. CrossrefGoogle Scholar33. DUBIN IN: The poverty of the immunological mechanism in patients with Hodgkin's disease. Ann. Intern. Med. 27: 898, 1947. LinkGoogle Scholar34. SCHIER WW: Cutaneous anergy and Hodgkin's disease. New Engl. J. Med. 250: 353, 1954. CrossrefMedlineGoogle Scholar35. KELLYGOODVARCO WDRARL: Anergy and skin homograft survival in Hodgkin's disease. Surg. Gynec. Obstet. 107: 565, 1958. MedlineGoogle Scholar36. SOKALPRIMIKIRIOS JEN: The delayed skin test in Hodgkin's disease and lymphosarcoma. Effect of disease activity. Cancer 14: 597, 1961. CrossrefGoogle Scholar37. SOUTHAMGOLDSMITH CMY: Effect of nitrogen mustard on serum complement in vitro and in patients with neoplastic disease. Proc. Soc. Exp. Biol. Med. 76: 430, 1951. CrossrefMedlineGoogle Scholar38. ROTTINOLEVY AAL: Serum-properdin levels in patients with Hodgkin's disease and carcinoma. Cancer 10: 877, 1957. CrossrefMedlineGoogle Scholar39. SOUTHAM CM: Personal communication. Google Scholar40. BRAUDEFELTESBROOKS AJM: Differences between the activities of mature granulocytes in leukemic and normal blood. J. Clin. Invest. 33: 1036, 1954. CrossrefMedlineGoogle Scholar41. HIRSCHBERG N: Phagocytic activity in leukemia. Amer. J. Med. Sci. 197: 706, 1939. CrossrefGoogle Scholar42. JERSILD M: Phagocytic activities of various types of leucocytes. Acta Med. Scand. 213 (supp.): 238, 1948. Google Scholar43. RIIS P: The Cytology of Inflammatory Exudate, a Study on Normal Subjects and Patients Showing Quantitative or Qualitative Changes in the White Blood Picture, Munksgaard, Copenhagen, 1959. Google Scholar44. SILVERBEALSCHNEIDERMANMCCULLOUGH RTGAMANB: The role of the mature neutrophil in bacterial infections in acute leukemia. Blood 12: 814, 1957. CrossrefMedlineGoogle Scholar45. HOFF F: Ueber Funktionsänderungen der Leukozyten. Wien. Klin. Wschr. 72: 495, 1960. MedlineGoogle Scholar46. GERMUTH FG: The role of adrenocortical steroids in infection, immunity and hypersensitivity. Pharmacol. Rev. 8: 1, 1956. MedlineGoogle Scholar47. KASSFINLAND EHM: Corticosteroids and infections, in Advances in Internal Medicine, Vol. IX, Year Book Publishers, Inc., New York, 1958, p. 45. Google Scholar48. ROBINSON HJ: Adrenal cortical hormones and infection. Pediatrics 17: 770, 1956. MedlineGoogle Scholar49. BOGGS D: The cellular composition of inflammatory exudates in human leukemias. Blood 15: 466, 1960. CrossrefMedlineGoogle Scholar50. JAFFE RH: Morphology of the inflammatory defense reactions in leukemia. Arch. Path. 14: 177, 1932. Google Scholar51. MILLERBUDINGERKARNFOSKY DGJMDA: A clinical and pathological study of factors influencing resistance to infection in chronic lymphatic leukemia. Cancer 15: 307, 1962. CrossrefMedlineGoogle Scholar52. KUSCHNERTHOMAS ML: Infection in disseminated neoplastic disease. Bull. N. Y. Acad. Med. 33: 684, 1957. MedlineGoogle Scholar53. WINTROBEHASENBUSH MMLL: Chronic leukemia. Arch. Intern. Med. 64: 701, 1939. CrossrefGoogle Scholar54. PARKES R: Hypogammaglobulinemia and tuberculosis. Implications of their association and other observations. Brit. Med. J. 1: 973, 1958. CrossrefMedlineGoogle Scholar55. JACKSONPARKER HF: Hodgkin's Disease and Allied Disorders, Oxford University Press, New York, 1947. Google Scholar56. EWING J: Neoplastic Diseases, 4th Ed., W. B. Saunders Company, Philadelphia, 1940. Google Scholar57. RAZISDIAMONDCRAVER DVHDLF: Hodgkin's disease associated with other malignant tumors and certain non-neoplastic diseases. Amer. J. Med. Sci. 238: 109, 1959. CrossrefGoogle Scholar58. COLLINSGELLHORNTRIMBLE VPAJR: The coincidence of cryptococcosis and discase of the reticulo-endothelial and lymphatic systems. Cancer 4: 883, 1951. CrossrefMedlineGoogle Scholar59. ZIMMERMANRAPPAPORT LEH: Occurrence of cryptococcosis in patients with malignant disease of reticuloendothelial system. Amer. J. Clin. Path. 24: 1050, 1954. CrossrefMedlineGoogle Scholar60. GENDELENDENORMAN BRMSL: Cryptococcosis. A review with special reference to apparent association with Hodgkin's disease. Amer. J. Med. 9: 343, 1950. CrossrefMedlineGoogle Scholar61. GREENCORSO IPF: A study of skin homografting in patients with lymphomas. Blood 14: 235, 1959. CrossrefMedlineGoogle Scholar62. MILLERDIAMOND DGHD: The biological basis and clinical application of bone marrow transplantation. Med. Clin. N. Amer. 45: 711, 1961. CrossrefMedlineGoogle Scholar63. BEILBYCADEJELLIFFEPARKINSTEWART JOISAMDMJW: Prolonged survival of a bone-marrow graft resulting in a blood-group chimera. Brit. Med. J. 1: 96, 1960. CrossrefMedlineGoogle Scholar64. WARRENGATES SO: Multiple primary malignant tumors. A survey of the literature and a statistical study. Amer. J. Cancer 16: 1358, 1932. Google Scholar65. OSGOODSEAMAN EEAJ: Treatment of chronic leukemias. JAMA 150: 1372, 1952. CrossrefMedlineGoogle Scholar66. LAWRENCEDONALD JHWG: The incidence of cancer in chronic leukemia and in polycythemia vera. Amer. J. Med. Sci. 237: 120, 1959. Google Scholar67. PISCIOTTAHIRSCHBOECK AVJS: Therapeutic considerations in chronic lymphocytic leukemia. Arch. Intern. Med. 99: 334, 1957. CrossrefGoogle Scholar68. MOERTELHAGEDORN CGAB: Leukemia or lymphoma and coexistent primary malignant lesions: a review of the literature and a study of 120 cases. Blood 12: 788, 1957. CrossrefMedlineGoogle Scholar69. GRABAR P: The problem of auto-antibodies. An approach to a theory. Texas Rep. Biol. Med. 15: 1, 1957. MedlineGoogle Scholar70. MILLER DG: Chronic lymphocytic leukemia and autoimmune disease. Unpublished material. Google Scholar71. BIENENSTOCK A: Personal communication. Google Scholar72. ROSENTHALPISCIOTTAKOMMINOSGOLDENBERGDAMESHEK MCAVZDHW: The auto-immune hemolytic anemia of malignant lymphocytic disease. Blood 10: 197, 1953. CrossrefGoogle Scholar73. EBBEWITTELSDAMESHEK SBW: Auto-immune thrombocytopenic purpura ("ITP" type) with chronic lymphocytic leukemia. Blood 19: 23, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL G. MILLER, M.D.Affiliations: New York, New YorkFrom the Lymphoma Section, Division of Clinical Chemotherapy, Sloan-Kettering Institute for Cancer Research; and the Departments of Medicine, Memorial Hospital for Cancer and Allied Diseases, James Ewing Hospital, and the Cornell University Medical College, New York, New York.Presented at the Forty-third Annual Meeting of The American College of Physicians, April 9-13, 1962, Philadelphia, Pennsylvania.This work was supported by grant CY-3215 from the National Cancer Institute.Requests for reprints should be addressed to Daniel G. Miller, M.D., Memorial Hospital for Cancer and Allied Diseases, New York 21, New York. 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SUSSMAN, M.D.Infections, fever and host resistance in neoplastic diseases 1 November 1962Volume 57, Issue 5Page: 703-716KeywordsCancer chemotherapyCancer immunotherapyHospital medicineLeukemiaLymphomaNatural history of diseasePneumoniaResearch laboratoriesSepsisSurgery ePublished: 1 December 2008 Issue Published: 1 November 1962 1962, by The American College of