Physical training and diet in obese patients with coronary heart disease reduced heart rate by 8.3% but produced no clinically relevant change in the QT interval (Bazett QTc -0.7%, P=0.007).
Observational (n=270)
Does a weight loss program with physical training and diet shorten the corrected QT interval in obese patients with stable coronary heart disease?
In obese patients with stable coronary heart disease, a weight loss program with diet and exercise reduces heart rate but does not produce clinically relevant shortening of the QT interval.
p-value: p=0.007
This study aims to describe the changes that a period of low-calorie diet and physical training determines in heart rate and in corrected QT (QTc) interval in obese patients with coronary heart disease (CHD) and to verify whether it is effective in shortening the QT interval using three different methods for QT correction. Two hundred and seventy obese white patients (162 males--60%) affected with stable CHD and treated with β-blockers were retrospectively studied in the setting of a program aimed at losing weight through training (aerobic activity + strength exercise) and diet (80% of estimated resting energy expenditure). Age was related to RR interval, QTc was related to left ventricular ejection fraction (EF) while sex exerted no effects. At the end of the study period heart rate decreased by 8.3% and noncorrected QT increased by 3.0%; QT corrected with the Bazett formula decreased by 0.7% (P = 0.007), QT corrected with the Fridericia formula increased by 0.5% (P = 0.023), whereas the modifications were nonsignificant when the Framingham correction was used. In conclusion, contrary to the current views, physical training and diet, which are effective in reducing heart rate, produced no clinically relevant change in the QT interval.
Gondoni et al. (Thu,) conducted a observational in Coronary heart disease in obese patients (n=270). Low-calorie diet and physical training was evaluated on Changes in heart rate and corrected QT (QTc) interval (p=0.007). Physical training and diet in obese patients with coronary heart disease reduced heart rate by 8.3% but produced no clinically relevant change in the QT interval (Bazett QTc -0.7%, P=0.007).