Basal anteroseptal calibrated integrated backscatter was significantly higher in preclinical hypertrophic cardiomyopathy mutation carriers compared to controls (-17.0 vs -22.6 dB, p<0.01), indicating early structural alterations.
Cross-Sectional (n=118)
No
The study aims to identify early structural and functional myocardial changes in preclinical HCM mutation carriers.
Absolute Event Rate: -17% vs -22.6%
p-value: p=<0.01
Background: To evaluate the presence of myocardial structural alterations and subtle myocardial dysfunction during familial screening in asymptomatic mutation carriers without hypertrophic cardiomyopathy (HCM) phenotype.
Yiu et al. (Fri,) conducted a cross-sectional in Hypertrophic Cardiomyopathy (HCM) mutation carriers (n=118). HCM mutation carrier status without phenotype expression (Mut+/Phen-) vs. Normal controls was evaluated on Basal anteroseptal calibrated integrated backscatter (cIBS) in dB (p=<0.01). Basal anteroseptal calibrated integrated backscatter was significantly higher in preclinical hypertrophic cardiomyopathy mutation carriers compared to controls (-17.0 vs -22.6 dB, p<0.01), indicating early structural alterations.