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A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.
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Oberdan Léo
M Foo
David H. Sachs
Proceedings of the National Academy of Sciences
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Léo et al. (Sun,) studied this question.
www.synapsesocial.com/papers/6a0c43293b45b6e808886665 — DOI: https://doi.org/10.1073/pnas.84.5.1374