Type 2 diabetes was associated with reduced heart rate variability and increased interleukin-6, with cardiac autonomic imbalance correlating with adipose tissue-derived inflammation.
Observational
Is cardiac autonomic imbalance associated with adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes?
Cardiac autonomic imbalance correlates with adipose tissue-derived inflammation early in type 2 diabetes, highlighting interrelated mechanisms that may contribute to increased cardiovascular risk.
INTRODUCTION: Diabetics die from cardiovascular disease at a much greater rate than nondiabetics. Cardiac autonomic imbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes. MATERIALS AND METHODS: Non-diabetics, newly diagnosed diabetics, and established diabetics were included. Anthropomorphic and biochemical measurements were obtained, and insulin resistance was approximated. Cardiac autonomic function was assessed using conventional measures and with power spectral analysis of heart rate. RESULTS AND DISCUSSION: Heart rate variability was reduced in all diabetics. Interleukin-6 was higher in diabetics, as was the high molecular weight adiponectin-to-leptin ratio. Interleukin-6 correlated negatively with measures of autonomic balance. Ratios of adiponectin to leptin correlated positively with measures of autonomic balance. Cardiac autonomic imbalance and inflammation occur early in diabetes and are interrelated. CONCLUSIONS: Cardiac autonomic imbalance correlates with the adipose tissue-derived inflammation seen early in type 2 diabetes.
Lieb et al. (2011) conducted an observational in Type 2 diabetes. Type 2 diabetes vs. Non-diabetics was evaluated on Relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation. Type 2 diabetes was associated with reduced heart rate variability and increased interleukin-6, with cardiac autonomic imbalance correlating with adipose tissue-derived inflammation.