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Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity | Synapse

September 19, 2011Open Access

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Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity

HNHong‐Min NiUniversity of Kansas Medical Center ABAbigail Bockus NBNikki BoggessUniversity of Kansas Medical Center

Key Points

Key points are not available for this paper at this time.

Abstract

APAP overdose induces autophagy, which attenuates APAP-induced liver cell death by removing damaged mitochondria.

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Cite This Study

Ni et al. (Mon,) studied this question.

synapsesocial.com/papers/69df6e0135659245ec614e5b https://doi.org/https://doi.org/10.1002/hep.24690

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1Is mitochondrial generation of reactive oxygen species a trigger for autophagy?2008 · 235 citations
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3Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice1988 · 211 citations
4Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.1985 · 169 citations
5Autophagy as a Regulated Pathway of Cellular Degradation2000 · 3,606 citations