Ischemic time >4 hours independently predicted plateau BNP in the upper quartile (OR 7.1, p=0.02) during the first year after pediatric heart transplantation.
Observational (n=50)
No
What are the trends and predictors of B-type natriuretic peptide (BNP) levels during the first year after pediatric heart transplantation?
BNP levels exponentially decline in the first 120 days after pediatric heart transplantation, and higher plateau levels are independently predicted by ischemic time >4 hours.
Effect estimate: OR 7.1
p-value: p=0.02
BNP is increasingly utilized in the management of pediatric HT recipients. Performing a retrospective single-center chart review, we sought to describe BNP changes during the first year after HT and identify factors that affect its trend. After exclusion for rejection, 316 BNP levels from 50 patients were evaluated. BNP underwent an exponential decline 120 days after HT followed by a plateau. Log10 BNP decline strongly correlated with time (r = -0.70, p 4 h, and those bridged medically were associated with higher plateau BNP. Multivariable logistic regression demonstrated IT >4 h independently predicted plateau BNP in the upper quartile (OR 7.1, p = 0.02). No significant change in BNP coincided with rejection (N = 6 patients) without severe hemodynamic compromise. BNP correlated modestly with right atrial pressure (r = 0.4652, p 4 h independently predicted higher plateau BNP and may reflect subtle changes in graft performance.
Sparks et al. (Thu,) conducted a observational in Pediatric heart transplantation (n=50). Ischemic time >4 hours was evaluated on Plateau BNP in the upper quartile (OR 7.1, p=0.02). Ischemic time >4 hours independently predicted plateau BNP in the upper quartile (OR 7.1, p=0.02) during the first year after pediatric heart transplantation.
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