In 539 Mexican Americans, weight change over 5 years was strongly associated with unfavorable changes in lipids, insulin, and blood pressure, explaining 2-10% of the variation in risk factor changes.
Cohort (n=539)
Are 5-year changes in weight and physical activity associated with changes in cardiovascular disease risk factors in Mexican Americans?
In Mexican Americans, weight gain over 5 years is strongly associated with worsening cardiovascular risk factors, particularly in lean individuals and men.
Recent changes in lifestyle have led to a global epidemic of obesity. To determine the associations of these changes with cardiovascular disease (CVD) risk, the authors correlated changes in CVD risk factors with changes in weight and physical activity in a population-based sample of 539 Mexican Americans in the San Antonio Heart Study in 1992-1999 who were examined twice approximately 5 years apart. Average weight change during that interval was 2.7 kg. While change in physical activity (expressed as percent change) was associated modestly only with change in low density lipoprotein cholesterol median diameter (p = 0.017), weight change was strongly and positively associated with unfavorable changes in lipid and lipoprotein traits, insulin levels, and blood pressure, explaining 2-10% of the variation in the risk factor changes during the interval. The unfavorable associations with weight gain tended to be more pronounced in lean compared with obese individuals and in men compared with women. However, the associations were significant for most CVD risk factors in all groups. In Mexican Americans, a population at high risk for obesity, weight change was positively correlated with metabolic variables associated with risk of CVD. Therefore, increasing adiposity in this population may tend to slow, or even reverse, the decline in CVD morbidity and mortality.
Rainwater et al. (Wed,) conducted a cohort in Cardiovascular disease risk factors (n=539). Changes in weight and physical activity was evaluated on Changes in cardiovascular disease risk factors (lipid and lipoprotein traits, insulin levels, and blood pressure). In 539 Mexican Americans, weight change over 5 years was strongly associated with unfavorable changes in lipids, insulin, and blood pressure, explaining 2-10% of the variation in risk factor changes.