Does oral anticoagulation therapy beyond 3 months after radiofrequency ablation of atrial fibrillation improve clinical outcomes regarding thromboembolism and serious bleeding?
Nationwide cohort of patients with atrial fibrillation in Denmark
Oral anticoagulation therapy (OAC) beyond 3 months after radiofrequency ablation (RFA)
Matched non-ablated atrial fibrillation cohort
Risk of thromboembolism and serious bleedinghard clinical
In a Danish nationwide cohort, the risk of serious bleeding with oral anticoagulation beyond 3 months post-ablation for atrial fibrillation appears to outweigh the benefits of thromboembolic risk reduction.
Thromboembolic risk beyond 3 months after RFA was relatively low compared with a matched non-ablated AF cohort. With cautious interpretation due to low number of events, serious bleeding risk associated with OAC seems to outweigh the benefits of thromboembolic risk reduction. Randomized studies are warranted to test our results.
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Deniz Karasoy
Gunnar Gislason
Jim Hansen
European Heart Journal
Rigshospitalet
University of Southern Denmark
Copenhagen University Hospital
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Karasoy et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69d2310904c37220ec4f76c3 — DOI: https://doi.org/10.1093/eurheartj/ehu421
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