LMW Heparin for Deep Vein Thrombosis

Letters1 August 1991LMW Heparin for Deep Vein ThrombosisRussell D. Hull, MBBS, MSc, Gary E. Raskob, MScRussell D. Hull, MBBS, MScSearch for more papers by this author, Gary E. Raskob, MScSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-3-231 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:We read with interest the article by Levine and colleagues (1) in a recent issue. Before accepting the investigators' conclusion that low molecular weight (LMW) heparin is significantly less hemorrhagic than standard unfractionated heparin (1), it is important to consider if the findings were caused by a dose effect rather than by a true property of LMW heparin. Because equivalent doses of standard and LMW heparin were not known, Levine and colleagues chose a fixed, arbitrary dose of 7500 units of standard heparin (1); the relevance of this dose, however, is uncertain because it is not typically...References1. LevineHirshGent MJM. Prevention of deep vein thrombosis after elective hip surgery. A randomized trial comparing low molecular weight heparin with standard unfractionated heparin. Ann Intern Med. 1991;114:545-51. LinkGoogle Scholar2. CollinsScrimgeourYusufPeto RASR. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic and urologie surgery. N Engl J Med. 1988;318:1162-73. CrossrefMedlineGoogle Scholar3. AlbadaNieuwenhuisSixma HHJ. Pharmacokinetics of standard and low molecular weight heparin. In: Lane DA, Lindahl U. Heparin. Chemical and Biological Properties, Clinical Applications. Boca Raton, Florida: CRC Press Inc.; 1989:417-31. Google Scholar4. BoucheloucheOstergaardMortensenPedersen PPSP. Comparative pharmacokinetics of a low molecular weight heparin (LHN-I, Novo) and conventional heparin after intravenous injection. Thromb Res Suppl. 1986;6:89. Google Scholar5. PlanesVochelleMazas ANF. Prevention of postoperative venous thrombosis: a randomized trial comparing unfractionated heparin with low molecular weight heparin in patients undergoing total hip replacement. Thromb Haemost. 1988;60:407-10. CrossrefMedlineGoogle Scholar1. LevineHirshGent MJM. Prevention of deep vein thrombosis after elective hip surgery. Ann Intern Med. 1991;114:545-51. LinkGoogle Scholar2. CyganWaitzkin RH. Stopping and restarting medications in the perioperative period. J Gen Intern Med. 1987;2:270-83. CrossrefMedlineGoogle Scholar3. PrinsHirsh MJ. A comparison of general anesthesia and regional anesthesia as a risk factor for deep vein thrombosis following hip surgery: a critical review. Thromb Haemost. 1990;64:497-500. CrossrefMedlineGoogle Scholar4. BarnesNixBarnesLavender RMCR. Perioperative asymptomatic venous thrombosis: role of duplex scanning versus venography. J Vase Surg. 1989;9:251-60. CrossrefMedlineGoogle Scholar1. PlanesVochelleMazas ANF. Prevention of postoperative venous thrombosis: a randomized trial comparing unfractionated heparin with low molecular weight heparin in patients undergoing total hip replacement. Thromb Haemost. 1988;60:407-10. CrossrefMedlineGoogle Scholar2. GreenLeeLim DMA. Prevention of thromboembolism after spinal cord injury using low molecular weight heparin. Ann Intern Med. 1990;113:571-4. LinkGoogle Scholar3. TurpieLevinePowers AMP. A double blind randomized trial of Org 10172 low molecular weight heparinoid versus unfractionated heparin in the prevention of deep vein thrombosis in patients with thrombotic stroke Abstract. Thromb Haemost. 1991; In press. Google Scholar4. PrinsHirsh MJ. A comparison of general anesthesia and regional anesthesia as a risk factor for deep vein thrombosis following hip surgery: a critical review. Thromb Haemost. 1990;64:497-500. CrossrefMedlineGoogle Scholar5. BonisChristiansenLassen LHM. Comparison of realtime B-mode ultrasonography and bilateral ascending phlebography for detection of postoperative deep vein thrombosis following elective hip surgery. Thromb Haemost. 1989;61:363-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Calgary Calgary, Alberta T2N 4N1 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Treatment of Proximal Vein Thrombosis with Subcutaneous Low-Mole Molecular-Weight Heparin Compared with Continuous Intravenous HeparinVenous Thromboembolism in Spinal Cord Injury PatientsTreatment of Venous Thromboembolism with Low Molecular Weight Heparins 1 August 1991Volume 115, Issue 3Page: 231-232KeywordsDeep vein thrombosisHeparin Issue Published: 1 August 1991 PDF DownloadLoading ...