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A communication means is presented for patients with amyotrophic lateral sclerosis in totally locked-in state who are completely unable to move any part of the body and have no usual communication means. The method utilizes changes in cerebral blood volume accompanied with changes in brain activity. When a patient is asked a question and the answer to it is ‘yes’, the patient makes his or her brain active. The change in blood volume at the frontal lobe is detected with near-infrared light. The instantaneous amplitude and phase of the change are calculated, and the maximum amplitude and phase change are obtained. The answer ‘yes’ or ‘no’ of the patient is detected using a discriminant analysis with these two quantities as variables. The rate of correct detection is 80% on average.
Naito et al. (Sun,) studied this question.