Candesartan cilexetil was equally effective as enalapril in reducing left ventricular mass index (15.0 vs 13.1 g/m2 reduction) in hypertensive patients with left ventricular hypertrophy.
RCT (n=239)
Double-blind
randomized
Yes
Does candesartan cilexetil reduce left ventricular mass index compared to enalapril in patients with essential hypertension and left ventricular hypertrophy?
Candesartan is as effective as enalapril in reducing left ventricular mass index and blood pressure in hypertensive patients with left ventricular hypertrophy, but with a lower incidence of cough.
Absolute Event Rate: 15% vs 13.1%
p-value: p=<0.001
BACKGROUND: A limited number of studies have evaluated the effect of angiotensin II receptor antagonists (AIIAs) on left ventricular hypertrophy (LVH) in comparison with other antihypertensive drugs, and no large study has compared AIIAs with angiotensin-converting enzyme inhibitors (ACEIs). METHODS AND RESULTS: The CATCH (Candesartan Assessment in the Treatment of Cardiac Hypertrophy) study was a multicenter prospective randomized double-blind trial comparing the effects of candesartan cilexetil (8-16 mg once daily) and enalapril (10-20 mg once daily) with possible addition of hydrochlorothiazide (12.5-25 mg once daily) on echocardiographic left ventricular mass index (LVMI), in 239 hypertensives with LVH (LVMI 120 g/m2 in men and 100 g/m2 in women). Two-dimensionally guided M-mode echocardiograms were carried out at screening (recruiting scan), randomization (baseline scan) and after 24 and 48 weeks of treatment. Baseline and treatment echocardiograms were read at two central labs without knowledge of the scan time sequence. In intention-to-treat (ITT) analyses (196 patients), systolic and diastolic blood pressures (SBP, DBP) were significantly and equally reduced by the two treatments. Candesartan and enalapril reduced LVMI to the same extent, i.e. by 15.0 and 13.1 g/m2 (-10.9 and -8.4%; P<0.001 for both). The proportion of patients achieving normalization of LVMI was non-significantly higher with candesartan (36.3 versus 28.6%). Similar results were obtained in per-protocol (PP) analyses. Cough incidence was lower with candesartan ( P<0.03). CONCLUSIONS: CATCH is the first large study comparing the effects of an AIIA and an ACEI on LVMI. Candesartan cilexetil was found to be equally effective as enalapril in reducing SBP, DBP and LVMI in hypertensives with LVH, according to both ITT and PP analyses.
Cuspidi et al. (Fri,) conducted a rct in essential hypertension with left ventricular hypertrophy (n=239). candesartan cilexetil vs. enalapril (10-20 mg once daily) was evaluated on reduction in echocardiographic left ventricular mass index (LVMI) in g/m2 (p=<0.001). Candesartan cilexetil was equally effective as enalapril in reducing left ventricular mass index (15.0 vs 13.1 g/m2 reduction) in hypertensive patients with left ventricular hypertrophy.
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