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Cerebrospinal fluid (CSF) obtained by suboccipital puncture from normal young males within 5–10 min after thiopental anesthesia contains a peptide with antidiuretic, oxytocic and frog bladder activities. Tryptic digestion of the CSF peptide suggests that it contains at least one basic amino acid. The biological activities of the new CSF peptide differ significantly from those of the known human neurohypophysial hormones but are not significantly different from those of synthetic arginine vasotocin (AVT).
S. Pavel (Thu,) studied this question.