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It is imperative to know how this dual action of ROS works during NLRP3 inflammation activation on different stimuli and what relevance such spatiotemporal redox regulation of NLRP3 inflammasomes has in cell or organ functions and possible human diseases.
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Justine M. Abais
Virginia Commonwealth University
Min Xia
Johnson & Johnson (United Kingdom)
Yang Zhang
John Innes Centre
Antioxidants and Redox Signaling
Virginia Commonwealth University
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Abais et al. (Mon,) studied this question.
synapsesocial.com/papers/69d6d0d539aaaf0da5ab37c4 — DOI: https://doi.org/10.1089/ars.2014.5994