The addition of valvular incompetence increases the spread of indicator particles in dye dilution curves, independent of cardiac output or volume.
Dye dilution curves can be used to estimate mitral regurgitation by analyzing the increased spread of indicator particles caused by valvular incompetence.
first showed it possible to estimate cardiac output from a mathematical analysis of dilution curves produced by the passage of an indicator substance through the circulation; good agreement was found between the cardiac output obtained by this and by the direct Fick method. They suggested that the volume between the point of injection and the site of sampling could be calculated from the product of the cardiac out- put and mean circulation time. More recently we have shown that for a given calculated output and volume the spread of the indicator particles in the curve is fixed within narrow limits (Korner and Shillingford, 1955, 1956). The addition of valvular incompetence in the passage of the indicator substance increases the spread of the particles quite apart from the effect ofcardiac output or volume TIME.
J. P. Shillingford (Tue,) conducted a other in Mitral regurgitation. Dye dilution curves was evaluated on Spread of indicator particles. The addition of valvular incompetence increases the spread of indicator particles in dye dilution curves, independent of cardiac output or volume.