Covalent Modifiers: An Orthogonal Approach to Drug Design

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTCovalent Modifiers: An Orthogonal Approach to Drug DesignMichele H. Potashman* and Mark E. Duggan*§View Author Information Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139* To whom correspondence should be addressed. For M.H.P.: phone, (617) 444-5010; fax, (617) 577-9288; e-mail, email protected. For M.E.D.: phone, (617) 583-1983; e-mail, email protected§Current address: Link Medicine Inc., 161 First Street, Cambridge, MA 02142.Cite this: J. Med. Chem. 2009, 52, 5, 1231–1246Publication Date (Web):February 9, 2009Publication History Received11 July 2008Published online9 February 2009Published inissue 12 March 2009https://pubs.acs.org/doi/10.1021/jm8008597https://doi.org/10.1021/jm8008597review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views16521Altmetric-Citations288LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Inhibition,Inhibitors,Monomers,Peptides and proteins Get e-Alerts