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MUCH OF THE published work dealing with 17-ketosteroid excretion has been concerned with the values obtained from patients with various endocrinopathies. While a large number of values from normal subjects have been published, the number in each paper is small and the results of different workers is difficult to integrate statistically, due to the various modifications of the Zimmermann method and the possible absence of homogeneity between the populations studied. The significance of extreme values is easy to evaluate, but some difficulty is encountered in interpreting the borderline values that are frequently found in studying the heterogeneous population encountered in general endocrine practice. Since most of the normal values published by American workers are expressed in terms of means and ranges, tests of significance are difficult to apply, either to the deviation of a clinical determination from normal values, or the difference between the results of two groups of workers.
Harold Wooster (Wed,) studied this question.