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A procedure for the radiosynthesis of aliphatic (18)Ftrifluoromethyl groups by reacting 1,1-difluorovinyl precursors with (18)Ffluoride ions, resulting in the equivalent of direct nucleophilic addition of H(18)FF, has been developed. A variety of (18)F-labelled model compounds were then obtained and two potential (18)Fradiotracers were synthesised by a two step process starting from 1,1-difluorovin-2-yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.
Riss et al. (Sat,) studied this question.