Major bleeding in stable CAD outpatients occurred at 0.6%/year and was significantly associated with increased mortality (adjusted HR 2.89; 95% CI 1.73-4.83; p<0.0001).
Cohort (n=4,184)
What is the incidence and prognostic impact of major bleeding, and does combining VKA with APT increase bleeding risk without cardiovascular benefit in outpatients with stable CAD?
In patients with stable CAD, major bleeding is rare but strongly predicts mortality, suggesting that concomitant antiplatelet therapy should not be prescribed with oral anticoagulation in the absence of a recent cardiovascular event.
Hazard Ratio: 2.89 (95% CI 1.73–4.83)
p-value: p=< 0.0001
BACKGROUND: Although there is evidence that patients who experience major bleeding after an acute coronary event are at higher risk of death in the months after the event, the incidence and impact on outcome of bleeding beyond 1 year of follow-up in patients with stable coronary artery disease (CAD) are largely unknown. OBJECTIVES: The goal of this study was to assess the incidence, source, determinants, and prognostic impact of major bleeding in stable CAD. METHODS: We prospectively included 4,184 consecutive CAD outpatients who were free from any myocardial infarction (MI) or coronary revascularization for >1 year at inclusion. Follow-up was performed at 2 years, with major bleeding defined as a type ≥3 bleed using the Bleeding Academic Research Consortium (BARC) definition. RESULTS: There were 51 major bleeding events during follow-up (0.6%/year). Most events were BARC type 3a bleeds with 12 fatal bleeds (type 5). In most cases (54.9%), the site of bleeding was gastrointestinal. Major bleeding was significantly associated with mortality (adjusted hazard ratio: 2.89; 95% confidence intervals: 1.73 to 4.83; p 1 year, with no acute events), major bleeding events are rare, but such events are an independent predictor of death. When oral anticoagulation is required, concomitant APT should not be prescribed in the absence of a recent cardiovascular event.
Hamon et al. (Mon,) conducted a cohort in Stable coronary artery disease (n=4,184). Major bleeding vs. No major bleeding was evaluated on Mortality (HR 2.89, 95% CI 1.73 to 4.83, p=< 0.0001). Major bleeding in stable CAD outpatients occurred at 0.6%/year and was significantly associated with increased mortality (adjusted HR 2.89; 95% CI 1.73-4.83; p<0.0001).
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