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Introduction CHANGES in the T wave, as well as in the ST segment, are among the most important electrocardiographic aids in the diagnosis of angina pectoris, myocardial infarction, and other ischemic and nonischemic conditions. Nevertheless, the pathogenesis of the T wave changes has been very difficult to ascertain owing to the great sensitivity of the T wave tobiochemical, biophysical, and other alterations of the myocardium.1-3Of the many previous experimental studies of T wave polarity and duration,4-9only one9that this laboratory is aware of has included simultaneous recordings of intracellular electrograms to demonstrate the membrane potential changes associated with the abnormal T waves. This problem was approached in the present investigation by application of electrographic techniques previously developed in acute myocardial ischemia.10,11The T wave changes were produced by perfusion ofcooledorheatedblood into the coronary artery.* Simultaneoussurfaceandintracellularelectrograms
Hideo Toyoshima (Fri,) studied this question.