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In a retrospective review of 912 patients with mammary cancer at the Ellis Fischel State Cancer Hospital (EFSCH), 199 patient records contained two or more gross measurements of a neoplastic focus in the breast, a lymph node, the lung, the chest wall, or other sites. The gross rates of growth were calculated from these measurements and correlated with the characteristics of the tumor and the hosts. The rates were independent of the anatomical site of the measured carcinoma, marital status, race, tumor size, frequency of lymph node metastasis at the time of mastectomy, and frequency and site of the postoperative metastasis. Doubling times did correlate directly with the age of the patients, duration of preoperative symptoms, and duration of survival after radical mastectomy. Tumor growth rate can account for some of the clinical characteristics of mammary carcinoma.
Kusama et al. (Tue,) studied this question.
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