January 1, 2014Open Access

SPARKLE (Subtypes of Ischaemic Stroke Classification System), Incorporating Measurement of Carotid Plaque Burden: A New Validated Tool for the Classification of Ischemic Stroke Subtypes

Structured PICO

Does the SPARKLE classification system improve the classification of ischemic stroke subtypes compared to CCS and TOAST?

Population

Patients with ischemic stroke

Intervention

SPARKLE (Subtypes of Ischaemic Stroke Classification System) incorporating measurement of carotid plaque burden

Comparator

CCS and TOAST classification systems

Outcome

Proportion of cases attributable to large artery disease (LAD) and proportion classified as 'undetermined' etiology

The SPARKLE classification system improves ischemic stroke subtyping by incorporating carotid plaque burden, thereby reducing the number of cases with undetermined etiology.

Abstract

SPARKLE is a valid and reliable classification system, providing advantages compared to CCS and TOAST. The incorporation of plaque burden into the classification of LAD increases the proportion of cases attributable to LAD and reduces the proportion classified as being of 'undetermined' etiology.

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