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AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of (3)Hdihydrostreptomycin and (3)Hgentamicin than did the parent strain.
Rosenberg et al. (Wed,) studied this question.