Enterococcal Superinfection and Colonization After Therapy with Moxalactam, a New Broad-Spectrum Antibiotic

Brief Reports1 June 1981Enterococcal Superinfection and Colonization After Therapy with Moxalactam, a New Broad-Spectrum AntibioticVICTOR L. YU, M.D.VICTOR L. YU, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-6-784 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMoxalactam is a new broad-spectrum antimicrobial drug that is structurally related to the cephalosporins (1). Its favorable pharmacokinetic properties allow it to be administered at 8-hour intervals (2), and unlike other cephalosporins, it reaches the cerebrospinal fluid in therapeutic concentrations (3). However, its major attraction is its effectiveness in vitro against many bacterial pathogens. It is active against the usual pathogenic gram-positive cocci (streptococci, pneumococci, staphylococci) as well as the Enterobacteriaceae (1, 4). Moreover, it is active in vitro against anaerobes (includingBacteroides fragilis) as well asHaemophilus influenzae(including ampicillin-resistant strains) andPseudomonas aeruginosa(4-6). No other commercially available...References1. NEUASWAPOKEEFUASWAPOKEE HNKP. Antibacterial activity of a new 1-oxa cephalosporin compared with that of other β-lactam compounds. Antimicrob Agents Chemother. 1979;16:141-9. CrossrefMedlineGoogle Scholar2. PARSONSROMANOLEVISON JJM. Pharmacology of a new 1-oxa-β-lactam (LY127935) in normal volunteers. Antimicrob Agents Chemother. 1980;17:226-8. CrossrefMedlineGoogle Scholar3. LANDESMANCORRADOCHERUBINGOMBERTCLERI SMCMD. Diffusion of a new beta-lactam (LY 127935) into cerebrospinal fluid: implications for therapy of gram-negative bacillary meningitis. Am J Med. 1980;69:92-8. CrossrefMedlineGoogle Scholar4. BARZATALLYJACOBUSGORBACH MFNS. In vitro activity of LY127935. Antimicrob Agents Chemother. 1979;16:287-92. CrossrefMedlineGoogle Scholar5. MASONKAPLANANDERSONHINDSFEIGIN ESDDR. In vitro susceptibility of 104 clinical isolates of Haemophilus influenzae to moxalactam (LY127935), ampicillin, chloramphenicol, and ticarcillin. Antimicrob Agents Chemother. 1980:17:470-3. CrossrefMedlineGoogle Scholar6. YUVICKERSZURAVLEFF VRJ. Comparative susceptibilities of Pseudomonas aeruginosa to 1-oxacephalosporin (LY127935) and eight other antipseudomonal antimicrobial agents (old and new). Antimicrob Agents Chemother. 1980;17:96-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh School of Medicine and Veterans Administration Medical Center Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeritonitis and Intraperitoneal AbscessesPeritonitis and Intraperitoneal AbscessesAntimicrobial resistance of enterococci in TurkeyMicrobiological and epidemiological studies of Enterococcus faecium resistant to amoxycillin in a university hospital in eastern FranceRisk Factors for Development of Vancomycin‐Resistant Enterococcal Bloodstream Infection in Patients with Cancer Who Are Colonized with Vancomycin‐Resistant EnterococciIn Vitro Assessment of Urinary Isolates of Ampicillin-Resistant EnterococciEffect of Antibiotic Therapy on the Density of Vancomycin-Resistant Enterococci in the Stool of Colonized PatientsThe influence of antibiotics on spread of vancomycin-resistant Enterococci: the potential role of selective use of antibiotics as a control measureRisk factors for enterococcal urinary tract infection and colonization in a rehabilitation facilityThe Challenge of Postoperative Infections: Does the Surgeon Make a Difference?Guideline for Prevention of Intravascular-Device–Related InfectionsGuideline for Prevention of Intravascular-Device-Related InfectionsColonization and infection with Enterococcus faecalis in intensive care units: the role of antimicrobial agentsDefinition of the role of enterococcus in intraabdominal infection: Analysis of a prospective randomized trialVancomycin Resistance in the Enterococcus: Relevance in PediatricsNew pathogens in pneumoniaHigh-Level Aminoglycoside Resistance Among Enterococci: Evaluation of an Agar Screen Susceptibility TestShort Communication: Effect of a Novel Parenteral Cephalosporin, E1077, on Normal Human Intestinal MicrofloraMicroorganisms and Diarrhea in Enterally Fed Intensive Care Unit PatientsTherapeutic effects of cefpirome (HR 810) on experimental mixed infections with enterococcus faecalis and escherichia coli in miceThe life and times of the EnterococcusLes cephalosporines dans le traitement des infections intra-abdominales: place de la ceririaxoneClinical implications of positive blood culturesNeonatal Septicaemia—Incidence, Etiology and Outcome A 6-year AnalysisCephalosporinsThe enterococci: Evidence of species-specific clinical and microbiologic heterogeneityNosocomial enterococcal infections: Association with use of third-generation cephalosporin antibioticsControlled trials of double beta-lactam therapy with cefoperazone plus piperacillin in febrile granulocytopenic patientsSpheroplast induction in clinical isolates of Serratia marcescens in the presence of Ca2+ or Mg2+Enterococcal urinary tract infections in a teaching hospitalThe Enterococcus: "Putting the Bug in Our Ears"STEPHEN A. 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