Is the 99th percentile of high-sensitivity cardiac troponin I a reliable index of silent cardiac disease in healthy children?
In healthy children, cTnI concentrations above the 99th percentile fluctuate across assessments and may indicate low-grade intercurrent illness rather than silent cardiac disease.
In this longitudinal study of cTnI concentrations in healthy children as determined by a high-sensitivity assay, different children had concentrations of cTnI above the 99th percentile at the 3 episodes of assessment. These results suggest that in children the 99th percentile may not be a reliable index of silent cardiac disease, but rather may be indicating low-grade intercurrent illness.
Koerbin et al. (Fri,) studied this question.