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A new diterpenoid, tolypodiol (1), has been isolated from the terrestrial cyanobacterium Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The monoacetate derivative 2 was prepared. Tolypodiol (1) and its monoacetate derivative 2 show potent antiinflammatory activity in the mouse ear edema assay.
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Michèle R. Prinsep
University of Waikato
Ralph A. Thomson
Waikato Institute of Technology
Michael L. West
Dalhousie University
Journal of Natural Products
The University of Queensland
University of California, Santa Barbara
University of Waikato
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Prinsep et al. (Mon,) studied this question.
synapsesocial.com/papers/6a036305f32c10a08381e914 — DOI: https://doi.org/10.1021/np9602574