In calves living with the TNS-Brno II artificial heart, initial degeneration of the nerve terminal system was followed by regeneration of the vegetative nerve system after 1 month.
This preclinical study demonstrates that vegetative nerve regeneration can occur in the remnant atrial stumps of calves surviving with an artificial heart for over a month.
The remnant stumps of the atria in six calves surviving with the artificial TNS-Brno II methacrylate heart for up to 5 months were examined by means of the Bodian silver-impregnating technique and by the formalin-induced fluorescence technique visualizing noradrenaline in monoaminergic nerve terminals. The degeneration of the nerve terminal system detected in animals surviving for 2 days and 1 week was followed by regeneration of the vegetative nerve system in four animals surviving for greater than 1 month. Moreover, thick myelinated nerves afferent in character were detected within the atrium of one animal surviving for 5 months.
Dolezel et al. (Fri,) conducted a other in Calves living with an artificial heart (n=6). TNS-Brno II artificial heart was evaluated on Innervation of atrial stumps (degeneration and regeneration of nerve terminal system). In calves living with the TNS-Brno II artificial heart, initial degeneration of the nerve terminal system was followed by regeneration of the vegetative nerve system after 1 month.
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