A decrease in tubular sodium chloride concentration at the macula densa results in a prompt stimulation of the renin release rate in isolated rabbit juxtaglomerular apparatuses.
Does a decrease in tubular sodium chloride concentration at the macula densa stimulate renin secretion in isolated rabbit juxtaglomerular apparatuses?
This study provides direct in vitro evidence that decreased sodium chloride concentration at the macula densa stimulates renin secretion independent of renal nerves and local hemodynamics.
An in vitro method has been used to examine whether secretion of renin from the juxtaglomerular apparatus is affected by changes in the sodium chloride concentration of the tubular fluid at the macula densa. Single juxtaglomerular apparatuses were microdissected from rabbits and the tubule segment containing the macula densa was perfused, while simultaneously the entire juxtaglomerular apparatus was superfused, and the fluid was collected for renin measurement. In this preparation, in which influences from renal nerves and local hemodynamic effects are eliminated, a decrease in the tubular sodium chloride concentration at the macula densa results in a prompt stimulation of the renin release rate.
Skøtt et al. (Fri,) conducted a other in Renin secretion. Decrease in tubular sodium chloride concentration was evaluated on Renin release rate. A decrease in tubular sodium chloride concentration at the macula densa results in a prompt stimulation of the renin release rate in isolated rabbit juxtaglomerular apparatuses.
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