WIN 51711 and WIN 52084 inhibit rhinovirus replication by inserting into the VP1 hydrophobic pocket and blocking the ion channel, preventing pH-mediated uncoating of viral RNA.
WIN 51711 and WIN 52084 inhibit rhinovirus replication by binding to the VP1 hydrophobic pocket and blocking ion channels, preventing viral uncoating.
WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the p H-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 β-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.
Smith et al. (Fri,) conducted a other in Human Rhinovirus 14 infection. WIN 51711 and WIN 52084 was evaluated on Mechanism of viral uncoating inhibition. WIN 51711 and WIN 52084 inhibit rhinovirus replication by inserting into the VP1 hydrophobic pocket and blocking the ion channel, preventing pH-mediated uncoating of viral RNA.
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