A family history of hypertension was associated with significantly higher average 24-hour systolic blood pressure compared to a family history of normotension (123 vs 113 mmHg; p<0.001).
Cross-Sectional (n=80)
Does a family history of hypertension associate with higher 24-hour ambulatory blood pressure in offspring compared to a family history of normotension?
Offspring of hypertensive parents have permanently elevated ambulatory blood pressure compared to offspring of normotensive parents, independent of office measurements.
Mean Difference: 10
Absolute Event Rate: 123% vs 113%
p-value: p=<0.001
24-hour ambulatory blood pressure (BP) was monitored by non-invasive methods in 42 offspring of hypertensive families (age mean (SD1) 40(7) years) and 38 offspring of normotensive families (age 33(6) years). The family history was defined according to parental BP data from two surveys conducted 27 years apart. Casual BP was 137(17)/84(12) mmHg in offspring of hypertensive families and 117(9)/69(6) mmHg in offspring of normotensive families (difference: p or = 139/87 mmHg--was found in 6 offspring of hypertensive families and in no offspring of normotensive families (p < 0.05). The 24-h systolic and diastolic BP load--the percentage of readings above 140/90 mmHg (day-time) and 120/80 mmHg (night-time)--was higher in offspring of hypertensive than normotensive families (27%/17% vs. 7%4%; p < 0.001). After adjustment for intrafamilial covariation, age, and other possibly confounding variables, the differences between the groups remained. The present findings suggest that BP in subjects with a family history of hypertension is elevated on a permanent basis, and not only when it is measured in the doctor's office.
Mo et al. (Fri,) conducted a cross-sectional in Family history of hypertension (n=80). Family history of hypertension vs. Family history of normotension was evaluated on Average 24-h systolic blood pressure (MD 10, p=<0.001). A family history of hypertension was associated with significantly higher average 24-hour systolic blood pressure compared to a family history of normotension (123 vs 113 mmHg; p<0.001).