Anticoagulant therapy after acute myocardial infarction reduced overall mortality in women from 31% to 15%, but did not reduce mortality in men (16% in controls).
Cohort (n=1,136)
No
Does anticoagulant therapy reduce overall mortality in patients with acute myocardial infarction?
The mortality benefit of anticoagulant therapy after acute myocardial infarction is highly dependent on patient age, sex, and infarct severity, with the greatest overall benefit seen in women.
The value of anticoagulant therapy after acute myocardial infarction has been assessed in 1,136 patients admitted to the Bronx Municipal Hospital Center. The treatment reduced the overall mortality in women from 31% to 15%, particularly those 55 years of age or over, with moderately severe infarction. The low overall mortality in control men (16%) was not reduced with treatment, though there was significant reduction of the mortality in a subgroup of men with moderately severe infarction showing Q-wave evolution. Age and sex, as well as the severity of the episode of acute myocardial infarction, are important in determining whether anticoagulant therapy is likely to be beneficial.
Arnold Drapkin (Mon,) conducted a cohort in acute myocardial infarction (n=1,136). Anticoagulant therapy vs. Control was evaluated on overall mortality. Anticoagulant therapy after acute myocardial infarction reduced overall mortality in women from 31% to 15%, but did not reduce mortality in men (16% in controls).