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We performed SPECT perfusion imaging and memory testing with mildly and moderately demented Alzheimer's disease (AD) patients and with healthy controls. All patients had memory abnormalities, but 5 of the 21 patients had neither temporal nor parietal perfusion abnormalities, indicating that temporoparietal blood flow may be normal at a point when memory is pathologic and the clinical diagnosis of AD is possible.
Reed et al. (Wed,) studied this question.