Hypertensive patients with normal LV relaxation had significantly lower mean systolic atrioventricular plane displacement compared to healthy controls (10.3 vs 13.1 mm, p<0.001).
Case-Control (n=131)
Does atrioventricular plane displacement (AVPD) estimation detect early left ventricular long-axis systolic dysfunction in hypertensive patients with normal ejection fraction?
In hypertensive patients with normal ejection fraction, long-axis systolic dysfunction detected by AVPD precedes diastolic dysfunction, serving as an early marker of hypertensive cardiomyopathy.
Absolute Event Rate: 10.3% vs 13.1%
p-value: p=<0.001
BACKGROUND: Atrioventricular plane displacement (AVPD) study by M-mode echocardiography can supply useful clinical information about left ventricular (LV) long-axis function. HYPOTHESIS: We assessed the hypothesis that AVPD estimation could be used to detect early hypertensive cardiomyopathy. METHODS: The study population included 81 hypertensive patients with normal LV ejection fraction and fractional shortening, and 50 age- and gender-matched healthy controls. By utilizing M-mode and apical views, the following parameters were estimated: early mitral flow peak velocity (E) and deceleration time (DT), peak velocity of late mitral flow (A), A/E ratio, isovolumic relaxation time (IVRT), total AVPD, AVPD motion during atrial systole (At), systolic AVPD (total AVPD-At), and At/total AVPD ratio. RESULTS: Of 81 hypertensive patients, 16 (19.7%) had a normal (Group 1) and 65 (80.3%) an impaired LV relaxation filling pattern (Group 2). Mean total AVPD-At was significantly lower in Group 2 than in Group 1 (7.1 +/- 2 vs. 10.3 +/- 3 mm, p0.05). CONCLUSIONS: Hypertensive patients without overt systolic dysfunction demonstrate LV long-axis systolic dysfunction, while long-axis diastolic dysfunction always coexists with abnormal diastolic filling patterns. This suggests that long-axis systolic dysfunction precedes diastolic dysfunction at the same axis in hypertensive patients.
Koulouris et al. (Wed,) conducted a case-control in Hypertension (n=131). Hypertension vs. Healthy controls was evaluated on Mean systolic atrioventricular plane displacement (total AVPD-At) (p=<0.001). Hypertensive patients with normal LV relaxation had significantly lower mean systolic atrioventricular plane displacement compared to healthy controls (10.3 vs 13.1 mm, p<0.001).