Cardiac resynchronization therapy largely reverses asynchronous electrical activation caused by left bundle branch block, and patient-specific tailoring with endocardial left ventricular pacing may increase therapy success.
Understanding the complex electrical and mechanical activation patterns in LBBB is essential for optimizing CRT delivery and improving patient response rates.
Cardiac resynchronization therapy (CRT) aims to treat selected heart failure patients suffering from conduction abnormalities with left bundle branch block (LBBB) as the culprit disease. LBBB remained largely underinvestigated until it became apparent that the amount of response to CRT was heterogeneous and that the therapy and underlying pathology were thus incompletely understood. In this review, current knowledge concerning activation in LBBB and during biventricular pacing will be explored and applied to current CRT practice, highlighting novel ways to better measure and treat the electrical substrate.
Strik et al. (Mon,) conducted a review in Left Bundle Branch Block and Heart Failure. Cardiac Resynchronization Therapy (CRT) was evaluated. Cardiac resynchronization therapy largely reverses asynchronous electrical activation caused by left bundle branch block, and patient-specific tailoring with endocardial left ventricular pacing may increase therapy success.
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