Does the CS-2000i automated analyzer perform comparably to the AggRAM aggregometer for light transmission platelet aggregation?
The CS-2000i automated analyzer offers comparable performance to stand-alone aggregometers for platelet aggregation testing, while requiring less sample volume and offering walk-away automation.
Our preliminary studies indicated that optimal sensitivity using the CS-2000i was obtained with a reaction cuvette stirrer speed of 800 rpm and a PRP platelet count of 200-300 x 10(9) /L; aggregation with a PRP count <100 x 10(9) /L showed poor sensitivity. Imprecision and detection of antiplatelet drug effects was similar between the CS-2000i and AggRAM. These data demonstrate that CS-2000i is comparable to a stand-alone aggregometer, although CS-2000i has the advantages of walk-away technology and also required a smaller sample volume than the AggRAM (44% less).
Lawrie et al. (Thu,) studied this question.