QRS dispersion, history of syncope, and right and/or left ventricular abnormalities at radionuclide angiography proved to be independent noninvasive predictors of sudden death in ARVC.
The natural history of arrhythmogenic right ventricular cardiomyopathy is determined by the electrical instability of the dystrophic myocardium, which can precipitate arrhythmic cardiac arrest any time during the course of the disease and by the progressive myocardial loss that results in ventricular dysfunction and heart failure. Sudden death accounts for the majority of the fatal events but its occurrence is mostly unpredictable. There are no prospective and controlled studies assessing clinical markers that can predict the occurrence of life-threatening ventricular arrhythmias. However, the noninvasive risk profile, which emerges from retrospective analysis of clinical and pathologic series, is characterized by history of syncope, physical exercise, spontaneous ventricular tachycardia or ventricular fibrillation, right ventricular dysfunction, left ventricular involvement, right precordial negative T wave, right bundle branch block, QT-QRS dispersion, right precordial ST-segment elevation and late potentials. At present only QRS dispersion, history of syncope and right and/or left ventricular abnormalities at radionuclide angiography proved to be independent noninvasive predictors of sudden death.
Turrini et al. (Tue,) conducted a review in Arrhythmogenic Right Ventricular Cardiomyopathy. Noninvasive risk stratification was evaluated on Sudden death. QRS dispersion, history of syncope, and right and/or left ventricular abnormalities at radionuclide angiography proved to be independent noninvasive predictors of sudden death in ARVC.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: