March 25, 2010

Acetone Cyanohydrin as a Source of HCN in the Cu-Catalyzed Hydrocyanation of α-Aryl Diazoacetates

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Abstract

A procedure for the Cu-catalyzed hydrocyanation of alpha-aryl diazoesters has been developed using acetone cyanohydrin as a source of hydrogen cyanide (HCN). It was found that the addition of trimethylsilyl cyanide (TMSCN) significantly accelerates the conversion presumably by delivering free cyanide ion in situ, thus producing various types of alpha-aryl cyanoacetates in high yields under mild conditions.

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www.synapsesocial.com/papers/69da262d34ded318bb684642 — DOI: https://doi.org/10.1021/jo100356d

Authors

Eun Ju Park

Seungeon Lee

Sukbok Chang

Journals

The Journal of Organic Chemistry

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Korea Advanced Institute of Science and Technology

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Acetone Cyanohydrin as a Source of HCN in the Cu-Catalyzed Hydrocyanation of α-Aryl Diazoacetates

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Abstract

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Discussion

Cite this study

Authors

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Institutions

References and Citations

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