Does sublingual isosorbide dinitrate improve maximal exercise capacity in beta-blockaded patients with angina?
Sublingual isosorbide dinitrate significantly improves exercise capacity when added to beta-blockade in patients with angina.
In 14 beta-blockaded anginal subjects, 10 of whom had poor left ventricular function, sublingual isosorbide dinitrate significantly increased maximal exercise capacity on a standardized multistage treadmill test. This was associated with changes in heart rate and blood pressure suggestive of a fall in left ventricular work. The effect of isosorbide lasts for at least two hours and when taken before exercise may be a useful addition to beta-blockade in patients with angina.
Baxter et al. (Sat,) studied this question.