Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis

Imagine—after a homogeneous reaction is complete, the chemist adds a catalyst or exposes the reaction mixture to soft UV light and pure product precipitates from the reaction mixture. This can be achieved with “precipitons”—protecting groups that have controllable solubility states. The first advances toward that goal are described (see scheme).