The activated partial thromboplastin time (PTT) showed an approximate linear correlation with the Lee-White coagulation time in 78 heparinized patients.
Observational (n=78)
Does the activated partial thromboplastin time (PTT) correlate with the Lee-White coagulation time for regulating heparin therapy in heparinized patients?
The activated PTT test is a rapid, laboratory-based alternative to the Lee-White coagulation time for regulating heparin anticoagulation.
In vitro and in vivo studies were carried out to determine whether a standardized laboratory procedure, the activated (kaolin) partial thromboplastin time (PTT), could be used to regulate heparin therapy. In vitro, increasing heparin concentrations caused progressive prolongation of both the Lee-White (L-W) coagulation time and the activated PTT. Comparison of the activated PTT with the L-W coagulation time in 78 patients revealed an approximate linear correlation between the two tests, with corresponding prolonged values for each test found in almost all heparinized patients. Our observations suggest that the activated PTT test procedure can be used to regulate heparin anticoagulation. The major advantage of this test is that it can be performed in the laboratory by trained technicians and completed within a few minutes.
Spector et al. (1967) conducted an observational in Heparinized patients (n=78). Activated partial thromboplastin time (PTT) vs. Lee-White (L-W) coagulation time was evaluated on Correlation between activated PTT and L-W coagulation time. The activated partial thromboplastin time (PTT) showed an approximate linear correlation with the Lee-White coagulation time in 78 heparinized patients.